Rejuran Eye: the latest innovation for the eye area—why it’s used and what to expect

The skin around the eyes is delicate and may show fine lines and changes in texture at an early stage. Rejuran Eye is an injectable polynucleotide-based treatment intended to improve skin quality in this area. Its primary purpose is not to add volume like a traditional filler.

What is Rejuran Eye?

Rejuran Eye is a polynucleotide-based treatment for the eye area. Unlike a volumizing filler, which aims to correct or restore volume, this treatment is designed to improve skin quality. A medical assessment helps determine whether it is suitable for the person’s skin and expectations.

Why might it be effective?

Polynucleotides are being studied in aesthetic medicine for their potential effects on factors such as skin elasticity, hydration, and texture. In a randomized study of 27 people, a polynucleotide-based treatment was compared with non-crosslinked hyaluronic acid in the periocular area. Overall aesthetic assessments were similar, while some texture measures showed greater improvement with polynucleotides.

A systematic review published in 2026 found promising short-term results in studies of polynucleotides for the eye area. However, the authors note that research is still limited and varied, and that none of the included studies followed patients for more than six months. For this reason, results cannot be guaranteed or automatically applied to every formulation or treatment protocol.

Is Rejuran Eye a filler?

It is not a traditional volumizing filler. The treatment focuses on skin quality and is not primarily intended to change facial volume. If the main concern is a hollow or loss of volume, the doctor will assess whether another approach may be more suitable.

What does the treatment process at PoliCologna involve?

At PoliCologna, the treatment is performed by Dr. Norma Amico, who specializes in aesthetic medicine for the face, neck, and décolleté. The initial assessment is an opportunity to discuss goals, skin condition, possible contraindications, and a treatment plan. The doctor determines the number and timing of sessions.

Temporary local reactions may occur after the injections, such as swelling, redness, or small bruises. The doctor provides aftercare instructions and explains which symptoms should prompt you to get in touch.

Book an assessment

To find out whether Rejuran Eye is suitable for you, you can request an assessment with Dr. Norma Amico at Policologna in Cologna Veneta.